The U.S. Food and Drug Administration (FDA), along with the Centers for Disease Control and Prevention (CDC), state and local partners in the U.S., and with the support of the Canadian Food Inspection Agency (CFIA), are investigating a multistate outbreak of E. coli O121 and E. coli O103 illnesses linked to ground bison supplied by Northfork Bison Distributions Inc. of Saint-Leonard, Québec, Canada.