The recent Cyclospora outbreak linked to shredded iceberg lettuce is a reminder of just how difficult modern foodborne outbreak investigations have become. In reality, food safety investigations rarely depend on a single "smoking gun." The future of ensuring food safety lies not in simply improving any one test or technology, but in integrating them into a comprehensive decision-support system.

Taking a page out of the pharmaceutical industry's pharmacovigilance playbook, this article discusses why Food Safety and Quality Assurance (FSQA) teams need to monitor product performance after reformulation or process changes—and how to start.