To prevent Clostridium botulinum poisoning, hygienic processing, especially during the heating and sterilization steps, must be maintained.

Traditionally, food safety issues associated with alcoholic beverages focus on chemical or physical hazards from the processing line. Intoxication with alcoholic beverages, as it relates to food safety, is less reported in the literature. However, the addition of cheap methanol to illicitly produced liquor—a rising issue in Asia—is increasingly being studied as a food safety and food adulteration issue.

Ciguatera toxin, which does not break down during cooking, can cause severe foodborne illness in humans who consume contaminated reef fish that feed on toxic microalgae. Climate change is altering algal and seaweed growth patterns, which may impact the rate of ciguatoxin accumulation by these fish species.

The key to preventing foodborne illness outbreaks associated with S. aureus, which is impervious to the cooking killstep, lies in the education of food handlers.